Sofiia Makedonskaia
Elevating Gynecologic Surgery in Cypress, USAPresentation Title:
The Role of Androgen Receptor in Ovarian Cancer Stemness and Chemoresistance
Abstract
Ovarian cancer's high mortality rate is partly attributed to cancer stem cells (CSCs) and chemoresistance. The androgen receptor (AR) regulates ovarian cancer stemness, promoting self-renewal, epithelial-to-mesenchymal transition (EMT), and stemness gene expression. AR expression correlates with chemotherapy resistance by activating anti-apoptotic pathways and regulating drug efflux transporters. Targeting AR through inhibitors or RNA interference, combination therapies, and investigating AR-mediated pathways offer promising translational research directions. Potential biomarkers include AR expression levels, AR gene mutations/variants, and CSC-specific markers. AR regulates ovarian CSCs, promoting stemness and chemoresistance, and its signaling enhances EMT, stemness gene expression, and anti-apoptotic pathways. Moreover, AR expression correlates with chemotherapy resistance, and targeting AR offers therapeutic potential. Biomarkers, such as AR expression levels and CSC-specific markers, may improve treatment strategies. This research highlights the critical role of AR in ovarian cancer stemness and chemoresistance, revealing potential therapeutic targets and biomarkers for improved treatment outcomes. Understanding AR's role may lead to novel therapeutic strategies, enhancing treatment efficacy and patient survival rates.
Biography
Dr. Sofiia Makedonskaia is a gynecologist-oncologist and endoscopist with over 15 years of experience in gynecologic oncology and infertility treatment. She specializes in performing advanced surgical procedures, including hysterectomies and cervical surgeries, aimed at improving the health and well-being of women with gynecologic cancers. Dr. Makedonskaia holds a Doctor of Medicine (MD) degree and a Master of Science (MSc) degree from Arden University in the United Kingdom. She graduated from Vladivostok State Medical University in Vladivostok, Russia. Currently, she practices in both Russia and the United States, dividing her time between Vladivostok and New York. She is an active member of international medical organizations, including Elevating Gynecologic Surgery in Cypress, USA. Dr. Makedonskaia's research interests focus on innovative approaches in gynecologic oncology, including minimally invasive surgical techniques and personalized treatment strategies for women with recurrent gynecologic cancers.Presenter Name: Sofiia Makedonskaia.
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