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Professor Kylie O’Brien
Adjunct Professor at Torrens University; Adjunct Fellow NICM Health Research Institute, Western Sydney University, AustraliaPresentation Title:
Medicinal cannabis in women’s health
Abstract
Cannabis has been used for medicinal purposes for centuries across many cultures, including for women’s health conditions. The physiological basis for why it is effective in so many conditions is the endocannabinoid system (ECS), a complex neuro- and immune-regulatory cell signalling system that is responsible for homeostasis of most bodily systems. Components of the ECS are present in the reproductive organs in women. For example, ECS receptors are present in normal myometrial tissue and the ECS plays a role in myometrial contractility during menstruation. Cannabis sativa has thousands of constituents, the most well known being the two major phytocannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) but there are many other minor phytocannabinoids, plus terpenes and other constituents that contribute to its therapeutic effects. Constituents of cannabis interact directly and indirectly with the ECS. Surveys suggest that women are using medicinal cannabis for women’s health conditions including menopause symptoms and dysmenorrhoea. Cannabis research has established quite strong evidence of efficacy for its use in treatment of chronic pain, as well as comorbities such as anxiety. However, there is less clinical research into efficacy or effectiveness in menopause or dysmenorrhoea and accompanying comorbidities.
In this presentation, Professor O’Brien will explain the ECS, key therapeutic actions of medicinal cannabis and explain why medicinal cannabis shows promise in the treatment of common gynaecological conditions including dysmenorrhoea and the treatment of menopause symptoms. She will also discuss two observational studies that she is currently involved in, one investigating the effectiveness and safety of medicinal cannabis in women with primary dysmenorrhoea and the other in menopause symptoms.
Biography
Professor
O’Brien is one of Australia’s leading educators in medicinal cannabis (MC), the
first to receive level 1 CPD points from the Royal Australasian College of
General Practitioners. In 2021, she set up the International College of
Cannabinoid Medicine (iccm.co), an online learning platform for healthcare
practitioners focused on the evidence base of medicinal cannabis. She has
written two books: O’Brien & Blair, Medicinal Cannabis and CBD in Mental
Healthcare, Cham: Springer, 2021 and O’Brien & Sali, A Guide to
Integrative Oncology, Springer 2017.
An experienced
clinical researcher, she has recently conducted a two-year observational study
investigating the effectiveness and safety of medicinal cannabis, focused on:
chronic pain, anxiety, PTSD and multiple sclerosis. She is currently conducting
research into the effectiveness of medicinal cannabis in women’s health and has
launched an international study, the Lumir Mission Study, that aims to reach
over 1 million patients in four years.
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