Bogomolova Marina Vadimovna
Mother and Child Saint-Petersburg,, Russian FederationPresentation Title:
PGT-A pros and cons - Which treatment tactics to choose
Abstract
Introduction: As it has
been known for quite some time, the frequency of aneuploid embryos critically
increases with maternal age, so it is very important to perform Preimplantation
Genetic Testing for Aneuploidy (PGT-A) with advanced age patients. However,
there are a large number of studies that conflict each other. Several authors
report increased pregnancy rates and decrease the miscarriage rates, while
other authors find no significant differences after PGT-A and non-PGT-A cycles.
This may be due to problems such as invasiveness, technical limitations of the
PGT-A method, mosaicism, occurrence of de novo mutations, and the ability of
embryos to normalize. In our work, we compared the score assigned by the
EmbryoScope+ incubator and the result of PGT-A preimplantation genetic testing.
Materials and Methods: The
present study was conducted on the basis of the clinic "Mother and Child.
St. Petersburg" Russia. The study included the embryos of 106 women aged
24 to 46 years who applied to the Mother and Child Reproduction Clinic for
infertility treatment using ART from January 2022 to November 2023. For this
study, the patients were divided into 2 age groups - up to 39 years (77
patients, 171 embryos) and 40-46 years (29 patients, 52 embryos). A
retrospective analysis of the correlation of the embryo score assigned by the
artificial intelligence of the EmbryoScope+ new generation incubator with the
result of preimplantation genetic testing of PGT-A was performed.
Results: In the first
group of female patients, up to 39 years of age, 171 PGT-A-tested embryos were
included in the study. In the embryo cohort with a score of 9-8, the frequency
of euploid embryos was 71.2%, in the embryo cohort with a score of 7-6, the
frequency of euploid embryos was 55.9%, and in the embryo cohort with a score
of 5-4, the frequency of euploid embryos was 53.7%. In the second group of
female patients, 40 years and older, 52 PGT-A tested embryos were included in
the study. In the embryo cohort with a score of 9-8, the frequency of euploid
embryos was 50.0%, in the embryo cohort with a score of 7-6, the frequency of
euploid embryos was 30.8%, and in the embryo cohort with a score of 5-4, the
frequency of euploid embryos was 46.7%.
Conclusions: Our work
revealed positive dynamics of embryo evaluation using artificial intelligence
of the EmbryoScope+ incubator. In both groups of patients, the frequency of
euploid embryos was higher at EmbryoScope scores of 8 and higher than at scores
of 7-4, indicating that transferring embryos with high EmbryoScope scores
increases the chances of selecting an euploid embryo without PGT-A testing.
Thus, the use of the EmbryoScope+ incubator significantly reduces the
infertility treatment time. Further research is needed to improve the quality
of non-invasive embryo assessment.
Biography
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