Bani Kumar Mitra
The Federation of Obstetric & Gynecological Society of India, IndiaPresentation Title:
Endometriosis
Abstract
Endometriosis is a prevalent condition significantly affecting fertility, as well as the personal and social lives of couples. Historically, understanding the pathogenesis of endometriosis has been challenging. However, with advancements in technology, new insights into the etiology of endometriosis have emerged. These include the mechanisms of endometrial cell transport into the pelvic cavity, genetic risk factors, epigenetic modifications, somatic mutations, mesenchymal transition, and environmental factors such as bacterial contamination. Next-generation sequencing, novel analytical methods, identification of endometrial stem/progenitor cells, and organoid models have substantial implications for developing non invasive diagnostic tests. Saliva and endometrial fluid testing are on the horizon as potential diagnostic tools for identifying endometriosis. It is estimated that 25-50% of women with fertility issues have endometriosis, and 30-50% of women with endometriosis are infertile. The fecundity rate in women with endometriosis is low, at 0.02-0.01 per month. Recent studies have highlighted biological mechanisms that may link endometriosis and infertility, including endocrine and ovulatory abnormalities, poor oocyte and embryo quality, and implantation problems. Fertility treatment for women with endometriosis depends on various factors. Ovulation inducing agents have limited effectiveness in achieving pregnancy. Medically assisted reproduction (MAR), including gonadotropin stimulation and intrauterine insemination (IUI), is considered the first line of treatment. Operative laparoscopy can be offered for ASRM stage I/II endometriosis, ovarian endometriomas, and deep endometriosis to improve the chances of ongoing pregnancy. Assisted reproductive technology (ART) is indicated in advanced stages of the disease, if tubal function is compromised, in cases of male factor infertility, low endometriosis fertility index (EFI), or if other treatments have failed. Fertility preservation should be offered to young women with advanced endometriosis.
Biography
Bani Kumar Mitra has completed his MBBS from Nil Ratan Sarkar Medical College, Kolkata, West Bengal, India, DGO from University of Calcutta, DNBE from National Board of Examination, New Delhi, FRCOG from Royal College of Obstetricians and Gynecologists, Greater London, England. He is the Managing Director of Surgy Centre, a renowned Infertility Clinic in India. He has 40+ years professional experience in Infertility. He is developing low cost IVF Protocols for developing countries like India. He has delivered lectures in different aspect of Infertility all over India, Bangladesh, Malaysia, Indonesia, Philippines, Myanmar and Sri Lanka and Nepal. He contributed several chapters in books and published papers in journals.
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