We present the case of a 26-year-old woman initially diagnosed with a complicated tubal ectopic pregnancy, managed by laparoscopic salpingectomy. Subsequent histopathological examination revealed a partial hydatidiform mole arising in an ectopic location, an exceptionally rare entity, with only 132 cases reported worldwide up to 2022. Due to its low clinical suspicion and the fact that definitive diagnosis can only be established through histopathological evaluation supplemented by molecular studies, timely identification remains challenging yet crucial to prevent potential complications, including malignant transformation associated with gestational trophoblastic disease. This case report is complemented by a non-systematic review of the literature addressing definitions, incidence, diagnostic criteria, and follow-up considerations. Its purpose is to emphasize the importance of recognizing this uncommon pathology and to encourage a broader clinical perspective when evaluating patients with ectopic pregnancies.

Bárbara Soto Karl is a 26-year-old Chilean physician born in the mining town of Chuquicamata, Calama, known as the “City of Sun and Copper” in northern Chile. She completed her medical degree at the age of 25 years from the Universidad de Tarapacá, Arica, Chile, graduating in 2024. She is currently a first-year resident in Emergency Medicine at Universidad Andrés Bello, Chile.

Her clinical and academic interests focus on Emergency Medicine and Women's Health, particularly on the diagnosis and management of gynecological and obstetric emergencies. She has participated in clinical research and scientific publications in the fields of Gynecology, Obstetrics, Surgery, and Emergency Medicine. Her work is especially oriented toward improving the recognition and acute management of time-sensitive conditions affecting women's health and promoting evidence-based care in emergency settings.